Effect of Resveratrol on Total Oxidative-Antioxidative Status and DNA Damage in Rats Induced Methotrexate
نویسندگان
چکیده
Bu çalışmada resveratrolün (RES) metotreksat (MTX) uygulanan ratlarda lökosit yüzdelerine, total oksidan (TOS)-antioksidan durumuna (TAS) ve DNA hasarına (8-OHdG) etkisi araştırıldı. Çalışmada kullanılan ratlar rastgele her biri 10 rattan oluşan 4 gruba ayrıldı. Gruplar, kontrol grubu, MTX grubu (20 mg/kg i.p., haftada 1 kez, iki hafta), RES (40 mg/kg/gün oral, 14 gün) MTX+RES i.p, hafta 40 olarak oluşturuldu. Deneme sonunda ratların kalplerinden kan örnekleri alındı, (nötrofil, eozinofil, bazofil, lenfosit, monosit) yüzdelerine klasik yöntemlerle, TOS, TAS, değerlerine kolorimetrik kitlerle, 8-OHdG seviyesine ELISA kiti ile bakıldı. gruplarındaki nötrofil (p≤0.05) monosit (p≤0.01) yüzdeleri grubuna göre istatistiksel önemde daha düşük olduğu belirlendi. Ayrıca, grubundaki, TOS OSI seviyelerinde anlamlı bir artış (p
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ژورنال
عنوان ژورنال: Cumhuriyet Üniversitesi sa?l?k bilimleri enstitüsü dergisi
سال: 2022
ISSN: ['2587-0874']
DOI: https://doi.org/10.51754/cusbed.1056908